Protective Effect of Thymus Deanesis Essential Oil Against Hypercholesterolemia Induced Destructionin Rat Testicular Tissue

Background: It has been suggested that Hypercholesterolemia has adverse effects on male sexual performance and testicular tissue. Thymus deanesis, a dietary compound with antioxidant properties, scavenges free radicals. The aim of present study was to explore the possible protective effects of Thymus deanesis Essential Oil against Hypercholesterolemia related damages in rat testicular tissue. Methods: In this experimental study, 24 male Wistar rats were randomly divided into four groups (n=6) including control, Thymus deanesis Essential Oil (500 mg/kg/day), Cholesterol (1/5 mg/kg/day) and Cholesterol + Thymus deanesis Essential Oil. After 30 days, the testicular tissues of all groups were removed and analyzed by hematoxylin-eosin staining. Results: Oral administration of Cholesterol decreased body and testes weights in the malerats. Moreover, Cholesterol treatment caused remarkable deterioration of testicular tissue. Interestingly, Thymus deanesis Essential Oil coadministration improves Hypercholesterolemia induced injurious changes in testicular tissue. Conclusion: Hypercholesterolemia can lead to significant testicular damages in rats. However, Thymus deanesis Essential Oil as a powerful antioxidant may have repro-protective effects in Hypercholesterolemia -treated animals.

کلیدواژه ها:

Thymus deanesis Essential Oil ، Hypercholesterolemia ، Testis ، Rat