Compare serum levels of interleukin-6 (IL-6) in acute pyelonephritis versus acute cystitis in 6 months to 12 years old children

Introduction : UTI is a common disorder in pediatrics and early diagnosis is important . However in young children diagnosis facing a problem which makes diagnosis hard .One of them is variety in sign and symptoms and for exact diagnosis in some case need expensive modalities . So new way is needed . il-6 at last decades preferred toUtI diagnosis and upper / lower involvement differentiation. So according to contrariety in IL-6 accuracy of plasma IL-6 in diagnosis and its power for differentiating upper from lower involvement.Material and methods: at this descriptive study , 83 patients were included and examined for interlukin -6 value in both urinary tract diagnosis and upper/lower involvement differentiation . Demographic characteristics like age , gender , history , physical examination beside of blood work like white blood cell count , ESR, CRP , IL-6 done and listed . Descriptive parameters report by mean and frequency for statistical analysis done t- test in SPSS16 . ROC curve downs for diagnosed value .Results : in this study 83 patients ( 14 control group , 33 ( 39.8%) cystitis , 36 ( 43.4%) pyelonephritis with 3.93+_3.069 mean age enrolled .Age distribution in this study 20 , 63 for male and female respectively . The interlukin -6 level in cystitis was higher than control and but this is not significant . In ROC curve sensivity and specificity of IL- 6 for cystitis 52% , 50% and for pyelonephritis 60% , 50% respectively .Conclusion : according to this study , IL-6 isnt a good Biomarker for UTI and differentiation Upper Tract involvement from the Lower Tract , A wide range of IL-6 level and useless of this Biomarker can be due to gender distribution ,time of diseasepresence , bacterial virulence and other factors . So suggestion for future studies on the large sample which parameters like gender distribution and other one mentioned controlled tightly