BK virus-associated hemorrhagic cystitis in children suffering malignancies: the report of three cases

BK virus-associated hemorrhagic cystitis is frequent in patients who undergoing bone marrow transplantation but it rarely occur among other immunosuppressed patients particularly in those who are planned for chemotherapy due to hematopoietic malignancies. Herein, we describes our experience on three children with burkitt lymphoma, leukemia and astocytoma undertreated with chemotherapy suffering HC due toBK virus infection that was successfully controlled and resolved. It can be concluded that by early detection of BK virus using RT-PCR technique and then administration of antiviral agents especially IVIG or leflunomide, BK virus-related HC can be successfully managed in children affected by malignancies that their treatment by chemotherapy can be even continued after virus elimination