The effect of hydro-alcoholic tribulus terrestris .L extract on serum interleukin-6 and CRP levels in polycystic ovary syndrome as an inflammation state

Background: Having low-grade chronic inflammation state symptoms such as elevated C-reactive protein and interleukin-6 play a crucial role in polycystic ovary syndrome (PCOS). Tribulus terrestris is an antioxidant and anti-inflammatory agent. In this study, we showed that Tribulus terrestris may have beneficial effects on the chronic low-grade inflammatory background associated with PCOS.Methods: This study was conducted on 72 Wistar rats with the average weight of 200±20 gr. PCOS was induced by a single-stage subcutaneous injection of Estradiol Valerate (2 mg⁄kgBW). PCOS rats were divided into control and experimental groups received intraperitoneal injection Tribulus terrestris extract (100 and 250 mg/kg, 2 weeks). Anesthesia with chloroform was administered for animals. Ovary and serum were taken to measure the inflammatory marks using ELISA kits and histomorphometric studies. The results were tested using one way ANOVA and PResult: The results indicated the significant reduction in inflammatory markers such as IL-6 and CRP in the treatment group with Tribulus terrestris extract compared with control.Conclusion: The results showed that the anti-inflammatory and antioxidant effects of Hydro-alcoholic Tribulus terrestris extract are effective in symptoms of this syndrome and metabolic syndrome.

کلیدواژه ها:

CRP ، IL-6 ، Tribulus terrestris ، Polycystic ovary syndrome