Orexin A role in regulating energy metabolism and metabolic syndrome in pregnancy and later in humans: a systematic review

Background: orexin A involved in regulating metabolism and energy balance, Desire and appetite and food acceptance , Reproduction and nightlife and stress. This review aims to summarize studies orexin A on the regulation of energy metabolism and metabolic syndrome in pregnancy and later in humans.Methods: In this study, 140 article through electronic search in databases Pubmed, Google, Google Scholar, Yahoo, Iran Medex, Science Direct, SID , the period of 1998 to 2016 was finally examined 10 articles.Result: The Results showed that, orexin A compared to non-pregnant, pregnant woman is increased in the brain and human placenta from 27 to 40 weeks of pregnancy, And be secreted And play important role in the regulation of energy metabolism and appetite during pregnancy by changing eating pattern and achieve proper weight And on the other hand, increased insulin sensitivity and increased glucose metabolism and reduce diabetes, hyperlipidemia loss, lower blood pressure and reduce heart disease - is vascular, As a result of reduced metabolic syndrome in pregnancy and later in humans.Conclusion: Studies have shown that, , orexin A plays a role in the regulation of energy metabolism and appetite during pregnancy in humans , And reduce the metabolic syndrome in pregnancy and later in humans

کلیدواژه ها:

energy metabolism ، metabolic syndrome ، pregnancy ، orexin A