The Role of orexin A and nesfatin - 1 in pregnancy and endometriosis in humans

Background: orexin A and nesfatin - 1 involved in regulating metabolism and Insulin sensitivity and Various organs of the body. This review aims to summarize studies The Role of orexin A and nesfatin - 1 in pregnancy and endometriosis in humans.Methods: In this study, 140 article through electronic search in databases Pubmed, Google, Google Scholar, Yahoo, Iran Medex, Science Direct, SID , the period of 1998 to 2016 was finally examined 20 articles.Result: The Results showed that there are nesfatin and orexin A in placenta and secretion and involved in the regulation of energy metabolism and diabetes and fetal development in pregnancy. However, two hormones are expressed in the endometrium. Reduce the level of Nesfatin - 1 (effect reducing anti-inflammatory and anti-apoptotic) and increases blood flow at increased vasodilatation are to the lesions of endometriosis And reduce its level does not depend on the degree and severity of endometriosis .orexin A role is unknown in endometriosis .Conclusion: Studies have shown that orexin A and nesfatin - 1 involved in improving pregnancy And nesfatin - 1 plays a role in reducing endometriosis.