Association assessment of the ERAP2 rs2549782 and rs17408150 gene polymorphisms with the incidence of preeclampsia in women of south of Iran

Background: Preeclampsia is a common disorder of pregnancy and the main cause of mortality and morbidity in women. The disease is inherited in a multifactorial mode of inheritance and the phenotypic manifestations vary due to the interaction of genetic background with environmental factors. ERAP2 gene encodes an aminopeptidase enzyme with increase in level during the primary stages of pregnancy. ERAP2 plays role in cleavage and activation of vasopressin to angiotensin II. Regarding the role of blood pressure regulation and immune-mediation of ERAP2, in this study the association between rs2549782 and rs17408150 polymorphisms with the risk of preeclampsia was investigated among southern Iranian women.Methods: In this case- 319 control patients and 291 healthy subjects were investigated. Genotyping of rs17408150A/T (CTA to CAA; L669Q) was done using tetra-primer amplification refractory mutation system (T-ARMS PCR). Data were analysed using SPSS v.19 software.Result: AA polymorphic genotype of rs17408150 considerably reduced the risk of disease. In the allelic level, decreased risk of the disease was also seen in the presence of A allele.Conclusion: Regarding the results, ERAP2 gene polymorphism can be used as a prognostic marker in at risk women.

کلیدواژه ها:

ERAP2 gene ، Iran ، Polymorphism ، Preeclampsia ، Aminopeptidase