Study of nitrat teratogenic effects on fetus of Balb / C mice on days 3, 4, 5 and 6 of pregnancy

Background: Nowadays, a wide range of materials as additives used in small quantities in the preparation of food.Methods: In this study, 60 female mice Balb / C were randomly divided into six groups: control, sham and experimental split 4,3,2,1 Shdnd.bh control no matter sham injection as, water was nitrate53 mg / kg.bw experimental groups 1,2,3 and 4 separately (6,5,4,3 days of pregnancy) were injected intraperitoneally. Then, the rats day 15 of pregnancy followed it Shdnd.ps comparative studies conducted sham control group the experimental group between the samples became a teratogenic embryos were studied.Result: The embryo of mice and sham control group no apparent abnormality, including: Agzansfal, Syndactylies, C-shaped body, skeletal body motor organs mice in the experimental group than the control group shamConclusion: can be viewed on slightly affect the growth of embryos so that in the experimental group fetal weight, placental weight, length CR, Qatar pairs, a significant decrease compared to the control groups and showed preservatives) are especially fast food and drinking water containing high levels of nitrite are avoided during pregnancy.

کلیدواژه ها:

pregnancy ، Preservatives ، Nitrate