Vitamin E and nanocurcumin in sole and simultaneous forms of administration partially provoke oxymethalone-reduced fertilizing potential

Background: Considering wide range usage of Nano-curcumin (NCMN), Vitamin E and low doses of Oxymetholone in various medication fields, evaluation of their possible side effect seems to be important. Present study was done to evaluate side effect of vitamin E, NCMN and Oxymetholone in female mice on in-vitro fertilization (IVF).Methods: Thirty adult female mice were randomly categorized into experimental and control groups. The experimental group subdivided into five groups, which orally received vitamin E-sole (100 mg/kg.bw), NCMN-sole (15 mg/kg.bw), Oxymetholone-sole (5 mg/kg.bw), vitamin E (100 mg/kg.bw) + oxymetholon (5 mg/kg.bw), NCMN (15 mg/kg.bw) + Oxymetholone (5 mg/kg.bw). After 21 days, the oocytes were picked-up by inducing superovulation (10 IU PMSG and 10 IU HCG) and underwent in vitro fertilization process by using fresh sperms from intact mice.Result: The oxymetholone-sole group exhibited a significant (PConclusion: Our data showed that, Oxymetholone negatively affects embryo development at all stages, and the vitamin E and NCMN are able to partially provoke embryo development.

کلیدواژه ها:

Fertilization ، Nanocurcumin ، Oxymetholone ، Vitamin E