Assessment of serum level of ANGPTL2 and its relationship with insulin resistance in the PCOs women with normal BMI

Background: Polycystic ovary syndrome is one of the most common endocrine disorders that associated with hyper-androgenism and chronic anovulation, affecting 5-8% of reproductive-age women; also at least 50% of PCOs women have insulin resistance. Angiopoietin-like2 (ANGPTL2) is a member of the ANGPTL protein family that is predominantly secreted from adipose and the heart tissue. ANGPTL2 promotes adipose tissue inflammation and subsequent systemic insulin resistance in obesity. The aim of this study was to assess the serum level of ANGPTL2 and its relationship with insulin resistance in the PCOs women with normal BMI.Methods: This research is a cross-sectional study which has done on 30 PCOs patients refereed to Abolfazal Clinic. They had normal BMI diagnosed according to the Rotterdam 2003 criteria. Also, 30 women who matched regarding age and BMI with cases were selected as healthy control group. Blood samples were obtained in the follicular phase. Biochemical parameters were measured by auto-analyzer. LDL levels were calculated by using the Friedewald formula. Serum levels of ANGPTL2, insulin, FSH, LH, TSH and Prolactin were measured by ELIZA.Result: There was no significant difference in demographic characteristics, serum concentration of lipids parameters, ANGPTL2, FBS, TSH, FSH and insulin between cases and control groups. A significant increase was observed in HOMA.IR, LH and Prolactin in the case group compared with the control group. A reverse relationship was observed between serum level of ANGPTL2 and HOMA.IR, Insulin level.Conclusion: Lack of significant difference of ANGPTL2 concentration in PCOS compared with control groups, can probably be attributed to the normal BMI.

کلیدواژه ها:

ANGPTL2 ، Insulin resistant ، Normal BMI ، Polycystic ovarian syndrome