Omentin in obesity and pregnancy : a systematic review

Background: Omentin is a good adipokine that plays a pleiotropic role in regulating the body metabolism. Omentin has an anti-inflamatory, antiatherogenic and insulin-sensitizing effect. Also, omentin plays a cardioprotective role. This review aims to summarize studies about omentin in pregnancy and obesity.Methods: In this study, 130 articles through electronic search in databases Pubmed, Google, Google Scholar, Yahoo, Iran Medex, Science Direct, SID, were reviewed during the period 998-2016 .Result: The Results showed that maternal omentin levels are higher in the first trimester compared to both the second trimester of pregnancy. The major source of maternal omentin is adipose tissue. Omentin is inversely correlated with BMI , total cholesterol, LDL cholesterol, triglycerides, obesity, insulin resistance and severity of preeclampsia. Omentin -1 (the most common form of circulating) is decreased in maternal plasma of pregnant women with pre-existing obesity. This adipokine plays a role in metabolic adaptation of normal gestation.Conclusion: Studies have shown that maternal obesity has adverse effect on feto-placental vasculature. Lower maternal plasma of omentin in obese pregnant women may have long-term effects on fetal development and growth.

کلیدواژه ها:

Insulin resistance ، Metabolic syndrome ، Obesity ، Pregnancy ، Omentin