Therapeutic effects of vitamin D supplementation on PCOS

Background: Women with polycystic ovary syndrome (PCOS) frequently suffer from metabolic disturbances including insulin resistance (IR), which might be related to vitamin D metabolism. This review study was conducted with aim of summarizing related studies with effect of vitamin D supplementation on insulin resistance in women with PCOS and a vitamin D deficiency Methods: In this study, all abstracts and full papers through electronic searches by entering the keyword in the databases PubMed, Science Direct, Google Scholar, and Google were obtained and studied from 2000 to 2015 .Result: The literature review indicates negative correlations of 25(OH)D levels with BMI, waist circumference, waist-to-hip ratio, systolic and diastolic blood pressure, fasting and stimulated glucose, area under the glucose response curve, fasting insulin, HOMA-IR, HOMA-β, triglycerides, and quotient total cholesterol/high-density lipoprotein (HDL) and positive correlations of 25(OH)D levels with QUICKI and HDL. PCOS women with the metabolic syndrom had lower 25(OH)D levels (Conclusion: The results of this study, low 25(OH)D levels are associated with features of the metabolic syndrom in PCOS women. Treatment with the vitamin D3 could be of value in the management of PCOS

کلیدواژه ها:

Metabolic syndrom ، PCOS ، Vitamin D