The effect of obesity on infertility: a systematic analysis of mechanisms

Background: Obesity is a common problem in today s society and is associated with numerous diseases. This study aimed to investigate the relationship between obesity and infertility and the mechanisms affecting it.Methods: In a systematic survey of the databases PubMed, Elsevier, Ovid, Clinical key, SID, IranMedex and etc. from 2005 to the present, the relevant articles were extracted and analyzed.Result: Findings showed that obesity leads to undesirable changes in hormonal, physical and Proteomics it. Also, obesity causes decreased levels of testosterone, inhibin B and ghrelin and increased levels of estrogen, leptin and rositin. Obesity is associated with erectile dysfunction and increasing the temperature of the testicles, resulting in infertility associated. Obese men have lower androgen HSBG and abnormal semen parameters are higher in them. The polycystic ovary syndrome (PCOS) that is one of the main causes of infertility is higher in obese people. Changes in diet and lack of exercise that could lead to infertility are higher in obese people. In general, an increase in BMI was associated with increased rates of infertility.Conclusion: As the findings show obesity has a very wide impact on the body that can lead to infertility. So, understanding of these mechanisms and the importance of obesity effects, could be very significant to control this problem and thus reduce related complications.

کلیدواژه ها:

Hormonal changes ، Infertility ، Mechanism of action ، Obesity ، Polycystic ovary syndrome