hypothalamic GnRH antagonist effect on hormone release gonadotropin (LH and FSH) in the follicular phase of the cycle and the beginning of GnRH IVF

Background: Most hormones secreted by the anterior pituitary releasing hormones that are produced in the hypothalamus and then through the port hypothalamic - pituitary anterior pituitary gland transmitted. Releasing hormones that are about Gnadvtrpynha importance, GnRH pulsatile GnRH Ast.trshh intermittent and around the hypothalamus causes pulsatile release of LH from the anterior pituitary. According to the antagonist in the treatment of IVF purpose of the study is the change in the antagonist protocol to enhance pregnancy rates Inclusion criteria for men and tubal infertility and condition exclusion (FSH Methods: In the intermittent release of GnRH, hypothalamic GnRH secretion is not continuous, but rather the rate of 25-5 per 1 minute or 2 hour infusion of GnRH secretion is required in the case Mynmayd.agr, we on the contrary, GnRH injection Rapyvsth not, so that is always available for discrete, can no longer causing the release of LH and FSH from the anterior pituitary gland. All patients routinely flexible antagonist protocol when a receipt is 13 mm follicle size; HMG / rFSH second day of menstruation starts from the dominant follicle and appropriately.It happened only 30 patients GnRH antagonist on days 1, 2 and 3 as groups receive menstruation. In the intermittent release of GnRH, hypothalamic GnRH secretion is not continuous, but rather the rate of 25-5 per 1 minute or 2 hour infusion of GnRH secretion is required in the case Mynmayd.agr, we on the contrary, GnRH injection Rapyvsth not, so that is always available for discrete, can no longer causing the release of LH and FSH from the anterior pituitary gland. All patients routinely flexible antagonist protocol when a receipt is 13 mm follicle size; HMG / rFSH second day of menstruation starts from the dominant follicle and appropriately.It happened only 30 patients GnRH antagonist on days 1, 2 and 3 as groups receive menstruation.Result: At the beginning of the menstrual cycle (with bleeding) adeno-pituitary gland, hormones LH and FSH releases. FSH effect on granulosa cells, stimulate oocyte production Gamtvzhnzys for the development of follicles and FSH under the control of two protein complex called Myknd.trshh Aktyvyn and Inhibin. In the beginning of the follicular phase with the effect of FSH on granulosa cells, produce Inhibin B increases.Along with the increase in FSH, Inhibin B in the follicular phase decreased when the egg is released and further reduce the amount of FSH. (At this point, most likely Inhibin A was secreted from the body (LH) plays a role.)If the egg is not released yet, there are still high levels of the hormone, probably trying to ovarian pituitary release of the egg, stimulate Lvytal At the end of the phase, atrophic corpus luteum, the production of estrogen and progesterone causes the effect at the beginning of the menstrual cycle FSH secretion inhibitor removal and a peak increase of FSH on the third day of menstruation is created.When the follicles about 8-10 mm in diameter (5-7 day cycle) production of estrogen, especially estradiol, which in turn significantly increases the growth of follicles and on the other hand the growth and development of endometrial also is merciful. At the beginning of the menstrual cycle (with bleeding) adeno-pituitary gland, hormones LH and FSH releases. FSH effect on granulosa cells, stimulate oocyte production Gamtvzhnzys for the development of follicles and FSH under the control of two protein complex called Myknd.trshh Aktyvyn and Inhibin. In the beginning of the follicular phase with the effect of FSH on granulosa cells, produce Inhibin B increases.Along with the increase in FSH, Inhibin B in the follicular phase decreased when the egg is released and further reduce the amount of FSH. (At this point, most likely Inhibin A was secreted from the body (LH) plays a role.)If the egg is not released yet, there are still high levels of the hormone, probably trying to ovarian pituitary release of the egg, stimulate Lvytal At the end of the phase, atrophic corpus luteum, the production of estrogen and progesterone causes the effect at the beginning of the menstrual cycle FSH secretion inhibitor removal and a peak increase of FSH on the third day of menstruation is created.When the follicles about 8-10 mm in diameter (5-7 day cycle) production of estrogen, especially estradiol, which in turn significantly increases the growth of follicles and on the other hand the growth and development of endometrial also is merciful.Conclusion: Serial ultrasonography, based on the need for endometrial thickness and size of the follicles do Mygrdd.zmany the size of dominant follicles was greater than or equal to 18 mm UHCG at a rate of 10,000 units injected the induce ovulation. Around the same time, approaching the menopause, the ovaries begin to resist and thus the pituitary hormone FSH, FSH produces more estrogen levels high to keep this mode activated, causing severe bleeding and menstrual irregularities Yi unpredictable will occur during the period.The absence of periods in a year and FSH levels above 30 MIU / ML represents the start of menopause. Given that the amount of FSH is very choppy near the menopause, FSH test only a result of Nyst.afzaysh stable enough for menopause, FSH sign that the normal negative feedback from ovarian issued, does not exist and thus LH and FSH enhanced. Serial ultrasonography, based on the need for endometrial thickness and size of the follicles do Mygrdd.zmany the size of dominant follicles was greater than or equal to 18 mm UHCG at a rate of 10,000 units injected the induce ovulation. Around the same time, approaching the menopause, the ovaries begin to resist and thus the pituitary hormone FSH, FSH produces more estrogen levels high to keep this mode activated, causing severe bleeding and menstrual irregularities Yi unpredictable will occur during the period.The absence of periods in a year and FSH levels above 30 MIU / ML represents the start of menopause. Given that the amount of FSH is very choppy near the menopause, FSH test only a result of Nyst.

کلیدواژه ها:

anterior pituitary ، follicle ، LH and FSH ، the menstrual cycle ، antagonist