Maternal killer-cell immunoglobulin-like receptor (KIR) and paternal human leukocyte antigen (HLA-C) genes relationship with risk of preeclampsia

Background: Among the approaches to preeclampsia, immune system and its involving molecules can be pointed out. Natural killer cells (NKs) are the most important cells in the fetomaternal immune tolerance inducing through interaction of maternal killer-cell immunoglobulin-like receptors (KIR) and fetal human leucocyte antigens (HLA). Hence, we intend to investigate maternal KIR, maternal and paternal HLA-C, and maternal-paternal KIR-HLA interaction in both preeclampsia and control groups.Methods: For this present case-control study, 200 couples participated in the study. DNA samples were genotyped based on polymerase chain reaction with specific sequences of primers (PCR-SSP) assay.Result: Among the maternal KIR genes, maternal HLA-C genes, and maternal KIR-HLA combinations, no significant deference was observed between the cases and controls. Paternal HLA-C genes and genotypes were significantly different between the cases and the controls. A significant relation was found for maternal KIR and paternal HLA combination. The relation was for the inhibitory combination KIR2DL1+HLA-C2 in the preeclampsia group.Conclusion: The inhibitory combinations of KIR-HLA seems to be more associated with preeclampsia. Prediction of preeclampsia with help of maternal KIR typing and paternal HLA-C typing can be possible in future.

کلیدواژه ها:

HLA-C ، PCR-SSP ، Preeclampsia ، KIR