The evaluation of LAP in women with polycystic ovarian syndrome

Background: Polycystic ovarian syndrome (PCOS) is one of the most prevalent heterogenic endocrine disorders with complex pathogenesis among women in reproductive age. Like insulin resistance, PCOS is regarded as a metabolic disorder and is one of the independent risk factors of some other metabolic disorders including dyslipidemia, defective glucose tolerance, rising in blood pressure, cardiovascular disease and metabolic syndrome. Noting that hyperinsulinemic-euglycemic Calmap gold standard method is complex and is not cost benefit and regarding that fasting insulin levels has not any reference intervals and is determined incorrectly, it has been necessary to use some insulin resistance indexes that are facile to detect, such as WC, BMI and LAP. The accurate evaluation of lipid accumulation product (LAP), HOMA-IR, WHR, WC are considered among biomarker of insulin resistance. The aim of this study was to assess the above indices in women with polycystic ovarian syndrome (PCOS).Methods: In this case control study , Antropometrics, biochemical parameters, LAP, and insulin resistance in 43 women suffering from PCOS as case and 40 healthy women as control were measured. LAP was defined as {WC(cm)-58, TG(mmmol/L)}. PCOS was diagnosed according to Roterdam standard. Insulin resistance was defined based on HOMA-IR. Statistical analysis was used to compare the WHR, WC, LAP, BMI . ROS curve was used to assess the insulin resistance.Result: The mean age, BMI, WHR among PCOS women were 24.06±5.86, 26.61±4.34 and 0.81±0.061. LAP index was 47.13±4.13.There was a direct significant correlation among HOMA-IR with WC,BMI, and LAP among women with PCOS.Conclusion: WC, BMI, LAP are among accurate and key indices in diagnosing insulin resistance among PCOS women, respectively. Although good relationship was between HOMA-IR and Calamp gold standard method in the present study, it is possible that this relationship is not significant among people with PCOS. We concluded that WC, BMI and LAP are indexes with facile detection and high accuracy that may be useful to monitor insulin resistance among women with PCOS. Future studies will use these indexes as factors to detect diabetes, as a marker of metabolic syndrome and to predict cardiovascular disease and mortality in comparison to other obesity indexes

کلیدواژه ها:

HOMA-IR ، LAP ، WC ، WHR ، BMI ، Polycystic ovarian syndrome