The effect of Xenical on the spermatogenesis index in hyperlipidemic male rats

Background: Xenical administration led to significant decreases in lipid plasma levels in hyperlipidemic patients. The aim of this study was to investigate the effect of Xenical by oral administration on spermatogenesis indexes in the testis of adult hyperlipidemic male rats.Methods: In this experimental study, 24 adult male wistar rats were allocated to 4 groups: control group received normal diet, control sham group received Xenical, hyperchlostromic group (administrated 0.1 ml/kg sweet almond oil,2nd group administrated 0.1ml/kg sweet almond oil plus 1ml/kg Xenical) by oral rout for 48 days. At the end, the testis tissue was sampled after passing above time and section providing, was stained by H&E. Histological and spermatogenesis indexes which included tubular differentiation index (TDI) and spermiogenesis index (SI) were studied. Data were analyzed by ANOVA at the significant level of PResult: This study showed that in hyperchlostromic rat, SI and TDI significantly decreased in comparison to control, while in treated groups with Xenical this parameter was improved. Also, administration of Xenicalin sham group significantly decreased rate of TDI and SI in comparison to control.Conclusion: According to the results, it seems that Xenical alone and hyperchlostromia cause reduction of spermatogenesis and its indexes in rat testis tissue, probably due to reducing cell dividing.

کلیدواژه ها:

Testis ، Xenical ، Hyperchlostromia