Polycystic ovary syndrome (PCOS) is affected and protected by DD and DI genotypes of angiotensin converting enzyme (ACE) respectively: An update of a meta-analysis

Background: Angiotensin converting enzyme (ACE) is an important enzyme involving in renal and cardiovascular systems physiopathology. One of these ACE related diseases is polycystic ovary syndrome (PCOS). We intend to update the only meta-analysis written by Jia et al. in 2013 about the association of ACE gene polymorphism and risk of PCOS. The reason of our attempt to update this meta-analysis was that they found no significant relation in their meta-analysis.Methods: For this aim, we searched some databases for relevant documents. Finally we found 8 relevant papers that 6 of them had been covered by that meta-analysis of Jia s et al. In order to perform this meta-analysis, we used comprehensive meta-analysis software. The analysis was done through P value and sample size of each study based on fixed-effect model.Result: Analyses were performed in five different groups of alleles and genotypes. Among these five analyses, four of them were statistically significant. DD genotype of ACE is a risk factor for PCOS in comparison to other genotypes (P value = 0.013; odds ratio = 1.195), while DI is the protecting genotype (P = 0.009; OR = 0.819).Conclusion: Hereby, we concluded that DD genotype of ACE is a risk factor for PCOS and DI is the protecting genotype. Hence it is suggested to use a very low dose of captopril as an ACE inhibitor in the PCOS patients having DD genotype in future as clinical trials.

کلیدواژه ها:

Angiotensin converting enzyme ، Meta-analysis ، Polycystic ovary syndrome