Predictive role of serum estradiol level in implantation rate of frozen-thawed embryos

Background: The successful outcome during in-vitro fertilisation (IVF) depends on optimizing ovarian-stimulation protocols that can result in good-quality oocytes and achieving pregnancy. Many factors affect the outcome of pregnancy. The role of estradiol (E2) in IVF cycles is well known in fertilization. They regulate follicle and oocyte maturation as well as preparation of the uterus for implantation. Some studies suggested that high E2 levels were not detrimental to the IVF outcome, while others revealed that high serum E2 levels result in uterine, receptivity. However, the role of E2 remains a controversial issue in reproductive medicine. The aim of current study was to determine the predictive role of serum estradiol level in implantation rate of frozen-thawed embryos.Methods: Retrospective cohort study was done on women aged 20–38 years who underwent IVF/ICSI cycle referred to infertility treatment center of Besat Hospital. Transfer of frozen-thawed was performed on day 3 embryos with administration of estradiol( E2 ) and progesterone (P4) supplemented cycles .Serum LH, FSH, estradiol, and progesterone concentrations were measured using an immunometric assay system.Result: A total of frozen cleavage stage embryos were thawed on the patients who participated during this study period. Embryos remained viable following thawing. A mean of 3 thawed embryos were transferred per patient. The overall implantation rate was 48 %, the clinical pregnancy rate was 45.3%. E2 serum levels were higher than in pregnant women as compared to non-pregnant women (p0.05).Conclusion: Results showed that serum E2 may be used to predict implantation or pregnancy outcome of day 3 frozen thawed embryos transferred in artificially programmed cycles.

کلیدواژه ها:

Embryos ، Frozen embryo ، Pregnancy ، Estradiol