The therapeutic approaches of immune system in breast cancer treatment.

Considering the recent evidence supporting the heterogeneous, prometastatic and poor prognostic property of breast cancer, immunotherapeutic approaches could play the important role in favor of treatment of breast cancer. In this review, we describe the current literature on promising immunotherapies for breast cancer, including tumor vaccine approaches, immune-checkpoint inhibitors, antagonists of immunosuppressive molecules and adoptive cell therapies. The use of T cell adoptive transfer, tumor infiltrating T cells (TILs) that accumulated around the cancer tissue and new antibodies against inhibitory receptors of T cells, such as anti-CTLA-4 (ipilimumab) and anti- PD-1 (Pembrolizumab), is particularly attractive. In breast cancer patients with poor prognosis, protein expression of αB-crystalline evaluation by immunohistochemistry (IHC) is one of the emerging methods in this field. Because of the heterogeneous nature of the breast cancer, utilizing immunological approaches along with conventional protocols such as surgery, chemotherapy and radiotherapy could be very effective. In conclusion, all attempts towards new therapeutic approaches, should considered breast cancer as a highly heterogeneous disease, implying that immunotherapeutic strategy could play a major role in cancer treatments.

کلیدواژه ها:

breast cancer ، Immunotherapy ، αB-crystalline and anti-cancer mAbs