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Comparison of clinicopathologic appearance and 5years survival of breast cancer in young (lessthan 40years ) and less young (40-50 years) women in Ostad Aalinasab Hospital in north westof IRAN (TABRIZ ) .

دهمین کنگره بین المللی سرطان پستان
سال انتشار: 1393
کد COI مقاله: ICBCMED10_129
زبان مقاله: انگلیسیمشاهده این مقاله: 240
نسخه کامل این مقاله ارائه نشده است و در دسترس نمی باشد

مشخصات نویسندگان مقاله Comparison of clinicopathologic appearance and 5years survival of breast cancer in young (lessthan 40years ) and less young (40-50 years) women in Ostad Aalinasab Hospital in north westof IRAN (TABRIZ ) .

Alikaram Hedayati Godarzi - professor of medical oncology, Consultant of OstadAlinasab Hospital in Tabriz
Fatemeh Hedayati - professor of medical oncology, Consultant of OstadAlinasab Hospital in Tabriz
Zahra Mokarram Ghazani - professor of medical oncology, Consultant of OstadAlinasab Hospital in Tabriz
Amir Mohammad Hedayati - professor of medical oncology, Consultant of OstadAlinasab Hospital in Tabriz

چکیده مقاله:

Background: Up to 7%of breast cancer cases occur in women younger than 40years in west world (greater than 25% in IRAN).Studies have suggested an association between breast cancer at a young age, poorer outcome, and adverse clinical and pathologic characteristics. It is unclear whether age is an independent prognostic factor.Objectives:To characterize the prognostic significance of young age at diagnosis through comparison of disease characteristics of young (less than 40 years) and less young (40-50 years old) premenopausal patients.Methods:Consecutive patients with breast cancer up to 50 years old in time of diagnosis, treated in Ostad Aalinasab hospital and our provide clinic in north west of IRAN (TABRIZ) between October 2002-november2o14were identified and their files reviewed(658 patients) .This cohort was identified as young (less than 40years old or group I=319 patients) and was compared with a group of less- young (40-50 years old or group II=339 ) patients .The clinicopathologic characteristics and survival data were compared.Results: Mean age were 35/2 years in group I (19-39years) and 46years in group II (40-50years).The form of pathology in group I were invasive intra ductal carcinoma in 83% and basal like in 7% and invasive intra lobular carcinoma in 8% and other type in 2% of cases, but in group II ,85% invasiveintra ductal and 5% basal like and 8%intra lobular and 2% other type. In group I , 24%were multifocal tumor but 15% in group II .The size of tumor or T in group I were 18% T1 and 47%T2 and 27%T3 and 8%T4 but in group II , T1 in 28% and T2 in47% and T3 in 20% and T4 in 5%were seen. Grade of tumors in group I were G3 or high grade in 68% and G2 in 19% and G1 in 13%, but in group II , G3 in 50% and G2 in 35% and G1 in 15%. Lymphovascular invasion was seen in 63% of group I but in 46% of group II. Axillary lymph node involvement was seen in 59% of group I but in 44% of group II. Stage of disease in the time of diagnosis group I were (20%stage I, 49%stage II, 21% stage III, 10%in stage IV) but in group II (26% stage I , 50% stage II, 16% stage III,8% stage IV ).61% of patients In group I and 76% of group II were ER+, 52% of patients in group I and 59% in group II were PR+.Her2 expression were seen in 31% of group I but in 21% of group II. 30% of patients in group I but 17% in group II were triple negative. Median follow up of patients in two groups after treatment was 60 month. Five years survival in very young patients was76%.but 84% in group II. Conclusions: young age(less than40 yo) among Iranian women with breast cancer is associated with higher stage at diagnosis, adverse pathologic characteristics (high grade, lymphatic and vascular invasion, ER negativity, triple negativity, and…) and adverse outcome when compared with less young patients (40-50yo), but probably age is not an independent prognostic factor for survival.

کد مقاله/لینک ثابت به این مقاله

کد یکتای اختصاصی (COI) این مقاله در پایگاه سیویلیکا ICBCMED10_129 میباشد و برای لینک دهی به این مقاله می توانید از لینک زیر استفاده نمایید. این لینک همیشه ثابت است و به عنوان سند ثبت مقاله در مرجع سیویلیکا مورد استفاده قرار میگیرد:

https://civilica.com/doc/726564/

نحوه استناد به مقاله:

در صورتی که می خواهید در اثر پژوهشی خود به این مقاله ارجاع دهید، به سادگی می توانید از عبارت زیر در بخش منابع و مراجع استفاده نمایید:
Hedayati Godarzi, Alikaram and Hedayati, Fatemeh and Mokarram Ghazani, Zahra and Mohammad Hedayati, Amir,1393,Comparison of clinicopathologic appearance and 5years survival of breast cancer in young (lessthan 40years ) and less young (40-50 years) women in Ostad Aalinasab Hospital in north westof IRAN (TABRIZ ) .,10th International Breast Cancer Congress,Tehran,https://civilica.com/doc/726564

در داخل متن نیز هر جا که به عبارت و یا دستاوردی از این مقاله اشاره شود پس از ذکر مطلب، در داخل پارانتز، مشخصات زیر نوشته می شود.
برای بار اول: (1393, Hedayati Godarzi, Alikaram؛ Fatemeh Hedayati and Zahra Mokarram Ghazani and Amir Mohammad Hedayati)
برای بار دوم به بعد: (1393, Hedayati Godarzi؛ Hedayati and Mokarram Ghazani and Mohammad Hedayati)
برای آشنایی کامل با نحوه مرجع نویسی لطفا بخش راهنمای سیویلیکا (مرجع دهی) را ملاحظه نمایید.

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