The Impact of Intraoperative Radiation Therapy in the Breast Cancer

Background: In general External Beam Radiotherapy (EBRT) is regarded as safe for most patients, however there are a number of side effects that can limit and in some cases avoid its use in breast cancer patients. Intraoperative radiotherapy (IORT) is a guaranteeing methodology for deliveringaccelerated, partial breast irradiation (APBI). For a woman with breast cancer, the prospect of receiving radiation therapy in a single dose during surgery, instead of experiencing six weeks of radiation medicines, is a welcome one. Objective: The aim of this study is assessing the role of intra-operative radiation therapy in the current management of breast cancer.Results: Restriction of radiation therapy to the tumor bed during surgery may be acceptable for selected patients. IORT delivery generally adds around 45 min to the operating room time. The method of reasoning for considering IORT in breast malignancy originates the way that around 85% of local recurrences show up in the tissue adjacent to the lumpectomy site within 5 years of treatment. For surgery alone, the recorded 10-year repeat rate is 10–30%. When postoperative radiotherapy is delivered, the local recurrence rate is under 10%. Since most recurrences are near the operative site, partial breast irradiation using IORT is an appealing alternative. Condensing the entire therapeutic dose into a single fraction, delivering the treatment at the time of lumpectomy in the operating room, and with the ability to spare normal surrounding tissue to a greater extent than perhaps any other form of APBI, IORT offers numerous potential advantage.Conclusion: In perspective of the number of publications identified with IORT, improvement and usage of randomized clinical trials for most cancer sites ought to be conceivable. Targeted IORT allowed the entire dose of radiotherapy to be directed in a single fraction at the time of breastconserving surgery, therefore avoiding the need for repeated radiotherapy treatments or placement of indwelling radiotherapy devices. Intraoperative radiotherapy in patients with a low risk of recurrence could be the only treatment required. In patients with high risk of recurrence, accurate targeting of intraoperative radiotherapy might improve on the conventional external-boost treatment

کلیدواژه ها:

IORT ، Breast Cancer ، Radiotherapy