Vitamin D Receptor (VDR) gene polymorphism is a risk for breast cancer

Breast cancer is by far the most common cancer among women globally. Epidemiological evidence suggests that vitamin D from sunlight and diet may be inversely associated with breast cancer incidence. 1,25(OH)2D3, the physiologically active metabolite of vitamin D, exerts growth regulatory functions by binding to the VDR. 1,25(OH)2D has antiproliferative effects on and promotes the differentiation of breast cancer cells. In MCF-7 cells, vitamin D and vitamin D analogs have been shown to induce cell cycle arrest and apoptosis, to downregulate estrogen receptorexpression, to limit responsiveness to the mitogenic effects of 17beta-estradiol, and to limit induction of the progesterone receptor.Epidemiologic evidence bearing on the relationship between vitamin D and breast cancer risk has come from several sources: ecologic studies, studies of vitamin D in relation to breast density, studies of VDR polymorphisms and breast cancer risk. The target of this study is investigation risk and incidence of VDR polymorphism in patients with breast cancer. Method: We studied recently published (2008-2014) and reviewed articles regarding Vitamin DReceptor and breast cancer. Results: More reviewed studies says that There is association between vitamin D receptor polymorphism and breast cancer. Also, some studies suggest that specific alleles of the VDR gene located near the 3 region may identify an increased risk for breast cancer and justify further investigation of the role of VDR in breast cancer. One study suggest that breast cancer risk may be associated with specific vitamin D-related polymorphisms, particularly CYP24A1. Genetic variation in the vitamin D pathway should be considered when designing potential intervention strategies with vitamin D supplementation. Some studies suggested that there were no associations between VDR BsmI polymorphism andbreast cancer. Conclusion: Vitamin D deficiency results of VDR genes polymorphism can be risk factor for breast cancer incidence.