The effect of Conjugated linoleic acids on tumor cells suppression and probably mechanisms of their effect

Conjugated linoleic acids (CLAs) are composed of positional and stereo isomers of octadecadienoate (18:2). They find in foods derived from ruminants (beef and lamb as well as dairy products from these sources). When a mixture of isomers is fed to experimental animals, chemically induced Cancer, tumorogenesis in mammary, prostate, colon and skin is decreased. Also CLA treatment has contributed to improvement disease outcomes in children with HPV-induced laryngeal papillomatosis during one-year crossover study, Mechanisms of inhibition of carcinogenesis may include reduction of cell proliferation, induction of apoptosis and alterations in the components of the cell cycle. In addition, CLAs modulate markers of immunity and also eicosanoid formation in numerous species as well as lipid metabolism and gene expression. It is likely that CLAs exert inhibitory properties in carcinogenesis via one or more of these pathways. This review will explain recent advances in Explore of putative mechanisms of reduction of carcinogenesis by CLAs.