New gene manipulation strategies against cancer stem cells

Cancer stem cells derived from a single cell that is transformed in to cancer initiating cell. Cancer stem cells have been reported in wide range of human tumour. It has capacity to proliferate and form in vivo. Cancers are responsible for overexpress cyclins. Thus, cell cycle arrest, represents a survival mechanism. There are some strategies for treatment of cancer stem cells, such as function of aldehyde dehydrogenase that focus on the role of retinoic acid and suppression of cell proliferation. In the other way, polyphenol structures and classifications are involved in the anti-cancer activities by interplay between autophagy and apoptosis. Polyphenols will target cancer stem cells. In addition, Hyaluronic acid could have coated in to the nanoparticles for targeting CD44 receptors on cancer stem cells. In other survey have been showed that, developing novel strategies against ErbB family which classified as a cancer stem cells to be responsible for tumour initiation and maintenance. In other strategies shows that Monoclonal antibody Cetuximab, in combination with ixabepilone has been eliminating cancer stem cell through inhibition of autophagy. MicroRNAs technology focused on preventing tumour recurrence and metastasis cancer stem cells. miR-34a is a key negative regulator of CD44+ as a novel therapeutic agent against CSCs. Also, infected cancer stem cell with lentiviral encoding pre-miR-34a inhibited tumour regeneration. In conclusion, new strategy such as monoclonal antibody, aptamers, microRNA could be targeted for stem cell cancer.

کلیدواژه ها:

Cancer stem cells ، monoclonal antibody ، microRNA ، targeted therapy