Personalized treatment in colon cancer

Colon cancer is one of the most prevalent cancer worldwide. It is estimated that , CRC is responsible for over 200,000 deaths each year. Like many other cancer types , colon cancer is a very good candidates for personalized treatment , since it s cancer cells uses many molecular alterations for proliferation and defencing against apoptosis . It is so important to know that the purpose of precision medicine in oncology is not to classify cancers only by site of origin , but to define the genomic alterations in the cancer DNA sequencing .Personalized cancer treatment use so many molecular testing to identify which type of cancer with which specific cancer genome is good candidate for a special targeted therapy .Therefore we will have the opportunity of having a unique treatment based on specific mutation and other cancer related change in the DNA programming of the malignant clone. In this way of attacking cancer cells , normal cells can be unaffected , and we will have more specific treatment besides less toxicity.Now our knowledge in studying molecular alteration in colorectal cancer is growing , and we do have many biomarkers for targeting , such as genetic mutations like KRAS and NRAS for anti EGFR , BRAF , PIK3CA , microsatellite instability high and may have more targets in near future.