Role of Micro-RNAs in Growth Hormone Deficiency: the Current Evidence

Introduction: Micro-RNAs (miR) are small RNAs encoded by downstream sequences of different genes. They play their roles through regulation of gene expression. Hence we intend to have a review on the recent evidence about the role of miRs in growth hormone deficiency.Methods: Scientific search engines were used in order to find papers. NCBI and miRDB database was used to assess to miR and genetic information. Results: Among the miRs, miR-15a, -26b, -29a, and -29b found to be associated with growth process. Most of them where in-vitro and animal studies. MiR-29a had a stronger evidence which was a human cohort study. This miR is down regulated by growth hormone replacement therapy and IGF-I. In addition it plays its role in myotubes and also insulin resistance level. The other miRs had similar functions but with lower evidence. Conclusion: Levels of the related miRs should be assessed in growth hormone deficiency children. As well these levels should be compared in responsive and resistant groups of replacement therapies. The evidence should be completed further because current drugs can be carcinogen.

کلیدواژه ها:

Micro-RNA ، child growth ، growth hormone deficiency ، personalized medicine