Tissue Engineered Cells in Breast Cancer

The incidence of breast cancer in the world is high, and this disease often causes metastasis and death. The treatment of breast cancer should be taken seriously. Chemotherapy today is widely used and due to its systemic effects, it has many side effects. So the new tissue engineering science is trying to help cure this disease with engineered methods. In recent years, as a result of advances in the tissue engineering and biomaterials fields, a small number of researchers have moved beyond simple gel culture systems and have started utilizing more tunable and mechanically superior polymer matrices as substrates for 3D cancer growth to provide a more well-defined architecture for tumor cell growth. Advances in tissue engineering have traditionally led to the design of scaffold- or matrix-based culture systems that better reflect the biological, physical and biochemical environment of the natural extracellular matrix. Healthy cells of the patient are used such as mesenchymal cells and by manipulating their cell cycle, they reduce the life of these cells. The drugs are loaded to these cells and injected directly into the cancerous tissue. Because the life of these cells has been reduced by manipulation, after multiple fractions in the cancerous tissue, they develop apoptosis. After mesenchymal apoptosis, the drug is released in the tumor tissue and plays its role.Conclusion: Tissue engineering can help prevent side effects and anticancer drug is used topically.

کلیدواژه ها:

Breast Cancer ، Tissue Engineering ، Apoptosis