Exosome based Technology in Personalized Cancer Medicine

سال انتشار: 1396
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 447

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شناسه ملی سند علمی:

IPMCMED02_032

تاریخ نمایه سازی: 29 فروردین 1397

چکیده مقاله:

Introduction: Exosomes are 50-150 nm membrane bound vesicles that act as shuttles between cells and can enter the body fluids and protect their cargoes from degradation. In recent years, exosomes have been emerged as an important player in tumor development. The present mini review article aimed to exploring exosome applications in cancer.Method: This mini review gathered from research and review studies published in valid databases including PubMed, Science Direct, Medline, Google scholar and Scopus using the following keywords: exosomes, cancer and personalized medicine. Result: Expression Changes in miRNA, lncRNA and other biomolecules in several type of cancer influenced by genetic and environmental factors that will be reflected by exosomes harvested from cancer patients, so making them promising tools in personalized medicine era. Since exosomes are transferred from their origin cells to target cells mostly through the circulation they can be harvested noninvasively from blood as potential biomarker for cancer diagnosis. Exosomes could serve as natural therapeutic nanovectors that are capable of carrying drug or small molecules for inhibition of tumor growth. Furthermore immunostimulatory and immunoinhibitory properties of some types of exosomes like dexosomes could be a choice for cancer immunotherapy. Nowadays the microfluidic technologies are introduced for exosome extraction which has some advantages including high purity and low cost rather than the routine isolation techniques like ultracentrifugation that make them ideal for clinical setting.Conclusion: In cancer patients, the contents of isolated exosomes would be different from healthy control which could be used as a potential biomarker in cancer diagnosis and therapy. Altogether exosomes investigations highlight a promising therapeutic strategy in personalized cancer medicine.

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نویسندگان

Mohammad Hasan Soheilifar

Research centre for molecular medicine and genetics, School of Medicine, Hamedan University of Medical Sciences, Hamedan,Iran

Abdolvahab Moshtaghian

Deputy of Research and Technology, Semnan University of Medical Sciences, Semnan, Iran

Razieh Amini

Research centre for molecular medicine and genetics, School of Medicine, Hamedan University of Medical Sciences, Hamedan,Iran

Masoud Saidijam

Research centre for molecular medicine and genetics, School of Medicine, Hamedan University of Medical Sciences, Hamedan,Iran