Fertility preservation in young women with breast cancer and pregnancy after

Introduction: Breast cancer is the most common malignancy in women of reproductive age. many breast cancer patients have not completed their family and wish to have children. In young breast cancer patients, adjuvant therapies may have some impact on fertility and ovarian function. Adjuvant chemotherapy can induce ovarian failure. These patients may benefit from a wide range of fertility preservation options. The present article discusses fertility-preservation options, prognosis and pregnancy after treating breast cancer. Material and methods: We considered many large studies reporting on fertility-preservation options, prognosis and pregnancy after treating breast cancer. Findings: Fertility preservation methods can protect the reproductive capability of the cancer survivors. A variety of techniques of fertility preservation are used in breast cancer patients such as: embryo and/or oocyte cryopreservation, ovarian stimulation protocols (with the aromatase inhibitor which is safe stimulation with endogenous estrogen.), ovarian tissue cryopreserved for future transplantation, retrieval of immature oocytes followed by in vitro oocyte maturation, coprescription of LH-RH analogues during chemotherapy and ovarian suppression with gonadotropin-releasing hormone agonists . Several studies addressing the potential risk of pregnancy after breast cancer have not revealed any negative effect on prognosis. The offspring of patients have shown no adverse effects and congenital anomalies from the treatment , but sometimes high rates of abortion (29%) and premature deliveries with low birth weight (40%) have been demonstrated. Pregnancies don’t increase the risk of recurrence or death from breast cancer. The offspring of breast cancer survivors do not appear to suffer deleterious consequences as a result of the diagnosis or treatment of the mother. Conclusions: Young adults with breast cancer who want to bear children in the future must be adequately informed at the time of diagnosis about the risk of infertility, available methods for fertility preservation and prognosis, in addition to advice about breast cancer treatment. Further research is required to define a safety period between cessation of treatment and pregnancy.

کلیدواژه ها:

Breast cancer ، Fertility preservation ، Adjuvant chemotherapy