Identification of Double Minute Chromosomes / Homogeneously Staining Regions in malignancies with special references to Breast Carcinoma

Background: Homogeneously Staining of Regions or Double MinuteChromosomes are autonomously replicating extra-chromosomal elements thatare frequently associated with gene amplification in a variety of differentcancers especially breast cancer.Materials and Methods: The diagnosis of leukemia patients was based oncharacterization of the leukemic cells, obtained from bone marrow cytogenetics.Results: This study report two cases, one with AML-M1, aged 23 years oldfemale, and the other with CML- blast crisis. A 28 years old female associatedwith Double Minute Chromosomes.Conclusions: Most cases of breast arcinoma and acute myeloid leukemia withdmin in the current literature (including our cases) have been diagnosed ashaving acute myeloid leukemia. More detail will be discussed.

کلیدواژه ها:

AML ، CML ، dmin ، HSRs ، Iran ، New case