Helicobacter Pylori in Children: Molecular Characterization, Antibiotics Resistance, and MLST of Isolated Strains in an Algerian Hospital
سال انتشار: 1396
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 506
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شناسه ملی سند علمی:
JR_IEM-3-3_001
تاریخ نمایه سازی: 26 فروردین 1397
چکیده مقاله:
Background: Helicobacter pylori infection is generally acquired in childhood. Algeria is a country with a high prevalence of H. pylori infection. The aim of this work was to take stock of H. pylori infection in Algerian children.Materials and Methods: About 31antral biopsies were cultured, and then antibiotic susceptibility testing was performed. The statuses of cagPAI and vacA s, m, I, and d regions were determined as well as geographical typing was done by Multi Locus Sequence Typing (MLST) method.Results: Culture was H. pylori positive in 12 children. Only one resistance to clarithromycin and one to metronidazole were detected. Four out of six strains possessed cagPAI, and five out of six strains were identified as vacA s2m2i2d2. The five strains tested by MLST were of the hpEurope type.Conclusion: This study revealed high prevalence of H. pylori infection and low resistance to antibiotics and reported for the first time in Algeria a genetic typing of H. pylori strains isolated from Pediatrics.
کلیدواژه ها:
نویسندگان
Naima Raaf
Department of Microbiology, Faculty of Nature and Life Sciences, University Ferhat Abbas, Setif, Algeria
Wahiba Amhis
Central Laboratory of Clinical Biology, Ibn Ziri Bologhine Hospital, Algiers, Algeria
Fadhila Benhassine
Pediatrics service, Ibn Ziri Bologhine Hospital, Algiers, Algeria
Safa Baiod-Chorfi
Pediatrics service, Ibn Ziri Bologhine Hospital, Algiers, Algeria