Cytotoxic effect of ceo2 nanoparticles that is synthesized by bistorta officinalis extract

All cerium oxide NPs does not display similar biological effects. There are some studies that reported prooxidant toxicity of NPs in some cases and antioxidant protective effects in others. The diverseabilities of cerium oxide nanoparticles (CONPs) have encouraged researchers to consider CONPs as a therapeutic agent to treat a number of disorders and diseases, including cancer. CeO2 nanoparticleshave shown hopeful achievement as therapeutic agents in biology and medical sciences. The physicochemical properties of CeO2-NPs, such as size, agglomeration status in liquid and surface charge, play important roles in the entire interac tions of the NP with target cells. Nowadays, CeO2 nanoparticles is synthesized through several biological process in order to prepare biocompatible CeO2-NPs, and also solving the challenges regarding safety and environmental issues, and providing the appropriate conditions for their effective use in biomedicine. Cytotoxic activity was determined using the MTT assay. Briefly, cells were seeded in 96-well plates with a confluence of approximately 70% (1 × 104). After cell adherence, the culture medium was removed and nanoparticles at different concentrations (5.10.20.50.100.200.500

کلیدواژه ها:

Breast Cancer ، Cancer Prevention ، Gene and Cancer ، Cell and Cancer ، Drugs and Cancer