Investigating anticancer effects of melphalan on malignant htlv-1 infected cells

سال انتشار: 1396
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 360

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شناسه ملی سند علمی:

NASTARANCANSER03_279

تاریخ نمایه سازی: 7 اسفند 1396

چکیده مقاله:

Adult T cell leukemia/lymphoma is a rare mature CD4 (+) T-cell neoplasm caused by HTLV-1 that is a complex human delta retrovirus. While HTLV-1 infection is generally asymptomatic, 3-5% of infectedindividuals develop the highly malignant and intractable T-cell neoplasm. In spite of medical advances, long term recovery of this disease has been failed. Melphalan is an alkylating nitrogen mustard that isused as an antineoplastic agent in a number of malignancies. In this study, the anticancer activity of melphalan was investigated on HTLV-1 infected cell line. In this regard, MT-2 cells were treated withincreasing concentrations of melphalan for 3 consecutive days. Then, cell viability was evaluated using Alamar Blue 14g% reagent. Obtained results indicated that 20 μg/ml melphalan caused 30% cell deathin comparison with relevant control treatment (0.8% DMSO ) after 72 hours. According to current study, melphalan could be considered as a potent anticancer agent in future studies

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نویسندگان

Faeze Khodadadi

Mashhad University Of Medical Sciences

Mohammad Hadi Sadeghian

Cancer Molecular Pathology Research Center, Department Of Hematology And Blood Bank, Faculty Of Medicine, Mashhad University Of Medical Sciences, Iran

Houshang Rafatpanah

Inflammation And Inflammatory Diseases Research Center, Faculty Of Medicine, Mashhad University Of Medical Sciences, Mashhad, Iran

Fatemeh B. Rassouli

Cell And Molecular Biotechnology Research Group, Institute Of Biotechnology, Ferdowsi University Of Mashhad, Mashhad, Iran