The recent studies show a high and increasing prevalence of cancer in the world. Vitamin D plays roles in a variety of biological actions (e.g. cancer). Today evidence exists which represents low levels ofcirculating vitamin D are associated with increased risk and mortality from cancer. Several studies have published an inverse relationship between cancer incidence and sunlight. These studies have offeredthat sunlight or high serum vitamin D status protects the risk of prostate cancer. Other in vivo and cell culture studies support the probability effect of vitamin D on preventing cancer progression anddevelopment. Renal and prostate cells can transform 25(OH) D to form 1,25-dihydroxyvitamin D. 1,25-dihydroxyvitamin D effects on the expression of plenty proteins that are effective in apoptosis,proliferation and cellular differentiation. Miller et al demonstrated that prostate cells have special feature high-affinity receptors to 1,25(OH)2D. The results show that Vitamin D preserve prostate cellsof oxidative destruction via up-regulating TR1 (thioredoxin reductase 1). Therefore, vitamin D or analogues can prevent induce apoptosis and cell growth via down-regulation from surviving by activation of p38 MAPK pathway and TGF-beta signalling. Findings of this review search in different databases search, as Google Scholar and PubMed were done for evaluating the association between Vitamin D and prostate cancer. A number of studies showed the document to association 25(OH) D status with prostate cancer. Increased exposure to light UV leads to decreased risk and mortality of prostate cancer. As well as VDR gene polymorphism can take part in risk prostate cancer. In aggregate, the findings support that vitamin D deficiency is related to increased risk of prostate cancer. There is a document from experimental studies that high doses rate of 1,25 (OH) 2 D prevent differentiation and proliferation in persons preliminary cultures of prostatic, cells prostate cancer, cell lines and also rodent samples of prostate cancer. Prostate cancers have decreased 1-alpha-hydroxylase activity, as a result, reduces the active form of vitamin D. Other research suggests that 1,25(OH)2D increase the differentiation and prevents the proliferation, metastasis and invasiveness of prostate cells. Generally, these findings led to identity active form of 1,25(OH)2D and also its analogues as the therapeutic factor to prostate cancer