The effects of sinomenine on cancers

Since the prevalence of cancer has grown today, researchers are looking to discover various and effective therapies. Sinomenine (SIN) is an alkaloid compound from Sinomenium acutum, a Chinesemedicinal plant, with an antineoplastic potential against a variety of cancer cells such as synovial sarcoma, lung, breast and hepatic cancer. Studies demonstrated SIN could inhibit breast cancer metastasis by blocking NF-kappa B activation and EMT pathways such as reducing expression of IL6, Janus kinase 2, STAT3 and vimentin. Also, Sinomenine treatment reduced miR-324-5p expression, thus increased the level of its target gene CUEDC2, and then suppressed the phosphorylation of IKK and inhibited breast cancer cell invasion and metastasis through regulation of the IL4/miR-324-5p/CUEDC2. Metastasis is still a severe challenge in cancer treatment especially osteosarcoma that can limit with sinomenine by suppressing CXCR4 and STAT3 phosphorylation then down-regulating theexpression of MMP-2, MMP-9, RANKL, and VEGF downstream. The effects of SIN against colorectal cancer are reduction of COX-2 expression, a marked increase in Cip1/p21 protein levels and a decrease in the levels of cyclin D1 and cyclin E. we did a search based on the keywords cancer AND sinomenine in Pubmed, EMBASE, Google Scholar databases.Due to the increasing incidence of cancer, the need to discover a new drug with more efficacy and fewer side effects is felt, so we can be used sinomenine according to the potential effects of it for treat varying types of cancer.

کلیدواژه ها:

Cancer Prevention ، Cell and Cancer ، Cancer Risks ، Cancer Treatment and Management ، Drugs and Cancer