Synthesis of new pyrazole derivatives in glycerol-potassium carbonate as eutectic solventandstudy of their antibacterial effects

One of the most important and most widely ring systems, heterocyclic compounds that are the foundationof manyChemical form of the derivatives of pyrazole according to many applications in agriculture,pharmacy and color are particularly important.pharmacological properties such as antitumor,antimicrobial, anti-inflammatory [1], antiviral , antifungal, analgesic, and anti-hyperglycemic activity.The pyrazole motif makes up the core structure of numerous biologically active compounds. One area thathas been intensely studied is their anticancer activity [2].In order to find better antitumor agents, a largenumber of pyrazole derivatives were synthesized and examined over the past several years [3]. So the useof this pharmacophore is still very powerful.An increase in regulatory restrictions on the use, manufactureand disposal of organic solvents has motivated the development of non-hazardous options for thedevelopment of green chemical processes. In this study, novel derivatives of 5-amino-1-(2,4-dinitriphenyl)-1H-pyrazole-4-carbonitrile 3-substituted a multicomponent reaction solvent one-poteutectic glycerol-potassium carbonate was synthesized.The main feature of this method to carry out thereaction at temperatures near room temperature, high efficiency, being an ecological process.Finallyinthis research project, we studied antibacterial effects of some newly synthesized pyrazole against B.cereus and S. typhimurium.

کلیدواژه ها:

Eutectic Solvents ، Green Chemist ، Pyrazole Derivatives