Kinetic and Structural Study of α-Glucosidase via XantheneHeterocycles as Antidiabetic Inhibitors

As a serious global health crisis, diabetes mellitus (DM) commonly referred to as diabetes is a commonmetabolic diseases, characterizing by abnormally high blood sugar level [1]. Therefore, avoiding widefluctuations in blood glucose levels are important goals in the therapy of the subjects with this metabolicdisorder [2]. Also, decrease of the postprandial hyperglycemia by inhibition of the carbohydratehydrolyzingenzymes is critical for treatment for glycemic control [3]. So, the inhibition of α-Glucosidase(α-Gls) is an effective method in both preventing and treating diabetes through improvement ofpostprandial hyperglycemia [4]. Therefore, beside the commercial inhibitors of α-Glucosidase such asacarbose, voglibose and miglitol which are widely in use for the treatment of diabetes, it is necessary todevelop more tolerable α-Glucosidase inhibitors with less unfavorable side effects. In the present study,the object of the research was to using some synthesized heterocyclic xanthene derivatives [5-6] to accesstheir inhibitory properties against α-Gucosidase. The results in this study may lead to present a new andmore specific α-Glucosidase inhibitors with potentially therapeutic values for reducing the severity ofthose secondary complications, which are normally associated with type-II diabetes mellitus.

کلیدواژه ها:

α-Glucosidase (α-Gls) ، Acarbose ، Diabetes mellitus ، Hyperglycemia ، Inhibition