Kinetic and Structural Study of α-Glucosidase via XantheneHeterocycles as Antidiabetic Inhibitors

سال انتشار: 1395
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 427

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تاریخ نمایه سازی: 7 اسفند 1396

چکیده مقاله:

As a serious global health crisis, diabetes mellitus (DM) commonly referred to as diabetes is a commonmetabolic diseases, characterizing by abnormally high blood sugar level [1]. Therefore, avoiding widefluctuations in blood glucose levels are important goals in the therapy of the subjects with this metabolicdisorder [2]. Also, decrease of the postprandial hyperglycemia by inhibition of the carbohydratehydrolyzingenzymes is critical for treatment for glycemic control [3]. So, the inhibition of α-Glucosidase(α-Gls) is an effective method in both preventing and treating diabetes through improvement ofpostprandial hyperglycemia [4]. Therefore, beside the commercial inhibitors of α-Glucosidase such asacarbose, voglibose and miglitol which are widely in use for the treatment of diabetes, it is necessary todevelop more tolerable α-Glucosidase inhibitors with less unfavorable side effects. In the present study,the object of the research was to using some synthesized heterocyclic xanthene derivatives [5-6] to accesstheir inhibitory properties against α-Gucosidase. The results in this study may lead to present a new andmore specific α-Glucosidase inhibitors with potentially therapeutic values for reducing the severity ofthose secondary complications, which are normally associated with type-II diabetes mellitus.


Maryam Nourisefar

Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran- UNESCO Chair on Interdisciplinary Research in Diabetes, University of Tehran, Tehran, Iran

Massoud Amanlou

Department of Medicinal Chemistry, Tehran University of Medical Sciences, Tehran, Iran

Farhad Panahi

Department of Chemistry, College of Sciences, Shiraz University, Shiraz ۷۱۴۵۴, Iran

Ali Khalafi- Nezhad

Department of Chemistry, College of Sciences, Shiraz University, Shiraz ۷۱۴۵۴, Iran