Production of controlled release oral drug delivery system using β-lactoglobulin nanoparticle

Over the past decades many efforts have been done to producecontrolled vehicle for sustained release oraldrug delivery system. The present study was performed whereas biopolymers were illustrated their abilityfor presence in nano-scale oral drug delivery system. Moreover, previous studies have shown β-Lactoglobulin (β-LG) as a milk whey carrier protein due to its unique physicochemical properties isknown as a well promising candidate for presence in oral drug delivery system [1-3]. In this study, β-LGnanoparticles contain metal based drug were fabricated in the presence of low methoxyl pectin as extralayer at various conditions. β-LG nanoparticles were characterized by dynamic light scattering andscanning electron microscopy so that the obtained results illustrated that the particle size average is lowerthan 200 nm and their shape is spherically. To determine controlled release manner of drug from β-LGnanoparticles, the in vitro drug release were studied using equilibrium dialysis methods at 37 °C during inthe simulation conditions of gastrointestinal (GI) tract. The results were investigated by fitting intomathematical kinetics models so that the Korsmeyer-Peppas model was the best kinetics release model. Inaddition, data illustrated that β-LG nanoparticles were resistance to acidic condition. Hence, anomalousnon-Fickian pattern was determined for drug release in the simulation time such erosion and diffusionwere occurred dependent on alkaline pH conditions of GI. Consequently, based on our findings β-LGnanoparticle is promising candidate with unique pH sensitivityfor presence in controlled release oral drugdelivery system.

کلیدواژه ها:

β-LG nanoparticles ، oral drug delivery ، mathematical modeling ، anomalous non-Fickian