Evaluation Of In Vitro Cytotoxicity Of Curcumin Nanomicelle And Free Curcumin Against A Colorectal Cancer Cell Line

Curcumin, a natural polyphenol derived from the rhizomes of turmeric (Curcuma longa), is a highlylipophilic molecule. Although curcumin showed potent anticancer and cancer preventive effectsdue to targeting various signaling pathways its clinical usage is limited due to poor bioavailability.Nanomicelle formulations of curcumin have been developed to enhance the bioavailability and thesolubility of this lipophilic compound. In this study the cytotoxicity of curcumin nanomicelleagainst C26 colorectal cancer cell line was evaluated in vitro by MTT assay. Nano-Curcumin is aregistered curcumin product (SinaCurcumin®) for use which has been developed in NanotechnologyResearch Center of Mashhad University of Medical Sciences, Mashhad, Iran and marketed by ExirNano Sina Company in Tehran-Iran (IRC:1228225765). colorectal cancer cell line were treated by thedrugs and incubated for 48 h. Cytotoxicity was examined by MTT assay. Our results indicated thatthe IC50 concentration of the micelle form of curcumin showed higher toxicity than that of nonmicelleform (25.02 vs 18.90 respectively). The micelle form of curcumin is expected to increase theefficacy of curcumin against C26 colorectal cancer cells.