Improvement of Citalopram Purity by Adsorption on Zeolite Solid Phase

After synthesis and manufacturing of drug, purification has a special place in pharmaceutical industries. For this purpose, common methods such as extraction, recrystallization, and column chromatography have been used for many years but some of them are expensive and not cost-effective. In present article, activated natural zeolite, clinoptilolite as an adsorptive solid phase for citalopram base and elimination of its impurities has been used for reaching over 99% purity in final product, citalopram hydrobromide. Citalopram hydrobromide is an antidepressant drug and selective serotonin reuptake inhibitor and its higher purity results in higher efficiency and lesser adverse drug reactions.

کلیدواژه ها:

Citalopram ، Purification ، Recrystallization ، Zeolite