Numerical simulation of breast cancer cell deformation in a microfluidic constriction

In this paper, deformation of a breast cancer cell (MCF-7)through a microfluidic constriction modeled as a singledroplet. Microfluidic constriction is being used forcharacterizing normal and cancer cell based on theirmechanical response to external forces due to the contraction.Two-phase level-set method used for tracking the interface ofthe droplet. Droplet distance to the first contact point withmicrochannel is validated with an experimental result inliterature. Influence of changing contraction width (CW) andcontraction angle (CA) on the entry time of the cell into theconstriction studied in detail. The obtained results can helpresearchers on understanding capillary blockage, beside ofcell mechanobiology