PHASE TRANSTION WITHULTRASONICWAVES IN ANTSOLVENT PRECIPITATION SYSTEM FORRAPD EFFICIENT PREPARATION NANOPARTICLES SUSPENSON OF AZTHROMYCIN

The aim of the present work was to prepare nanoparticles suspension by ultrasound waves in antisolvent precipitation system for enhancing availability of azithromycin (AZ) a poorly water-soluble drug. Use of high stream velocities enhances mixing of AZ ethanolic solution with water, whereas addition of polymers/surfactants inhibits/lowers the particle growth, was prepared a homogeneous solution. With ultrasound waves, phase transition was occurred and the AZ particles with size <100 nm was prepared. Several experimental parameters, such as the ratio of AZ to stabilizer, the type of stabilizer and the concentration of stabilizer, were investigated in the ethanol- deionized water system. The results showed that the best stabilizer is PVP (poly N-vinyl-2-pyrrolidone) 1 mg/ml that the produced nanosuspension had a mean particle size of 96 nm and size distribution 35- 200 m.

کلیدواژه ها:

Azithromycin ، Nanoparticle ، Ultrasound ، Antisolvent ، Precipitation ، phase transition