Role of Apoptosis in CNS Emphasizing Spinal Cord Injuries: A Commentary

Apoptosis is a kind of programmed cell death that is naturally necessary for homeostasis and some processes like organogenesis and implantationof embryo; so it is not pathologic and harmful all the time. The purpose of this commentary was to describe the ways of stimulating andinhibiting the apoptosis process; because rather in the therapeutic protocols we should stimulate or inhibit the process in order to minimize theeffects of the traumas and injuries. For using the first results in therapeutic protocols; for example, in order to take action against tumors, weshould stimulate apoptosis with chemotherapeutic drugs or other alternatives. On the contrary, in physical traumas of spinal cord, we shouldinhibit apoptosis with chemical drugs or other alternatives in order to reduce secondary paralysis and other side effects. By collecting the presentresults and comparing them with our previous original articles, we reached some ideas for the future original research and therapeutic proposals.

کلیدواژه ها:

Apoptosis ، Spinal Cord ، CNS ، Pathology ، Neuropathology