Synthesis and Characterization of Fe3O4 Coated on APTS as Carriers for Theophylline Drug

theophylline is a drug Anti-asthma. Fe3O4 magnetic nanoparticles (MNPs) coated on 3-aminopropyl triethoxysilane (APTES) were synthesized (MNPs-APTES) as carriers for theophylline. The characterization of drug delivery system was confirmed by Fourier Transform Infrared (FTIR), Scanning electron microscopy, X-ray energy dispersive techniques (SEM-EDX), X-Ray Diffraction (XRD) and vibrating sample magnetometer (VSM). The adsorbed APTES on the magnetite surface (MNPs-APTES) was examined by FTIR. The SEM image showed that the average particle size is obtained to be about16-51 nm for MNPs-APTES. The theophylline loading and release behavior of MNPs-APTES were studied and the results showed that up to 70% of the adsorbed drug was released within 6 h. In summary, the MNPs-APTES nanocarriers are based on the results, promising for targeted theophylline drug delivery.

کلیدواژه ها:

magnetic nanoparticles ، drug delivery ، release ، theophylline