Synthesis and Evaluation of Tramadol imprinted nanoparticle Polymers to study controlled release by using Miniemulsion Polymerization

Molecular imprinting is recognized as a powerful technique to synthesize polymer-type artificial receptors [1, 2]. This technology is attracting widespread attention because of itspotential to deliver robust molecular recognition elements targeted toward any guest really present in any environment(e.g., drug enantiomers, hormones, toxins, pesticides, peptides, proteins, and nucleic acids in matrixes ranging from pure organic solvents to biological fluids). Polymer systems that allow the controlled-release of a drug are well-established. In most recent studies, molecularly imprinted polymers (MIPs),materials with artificially fabricated receptor structures, have been used to develop the design of drug delivery systems (DDS). The molecular imprinting technology can provide polymeric materials with the ability to recognize specific bioactive molecules with sorption and release behavior thatcan be made sensitive to the properties of the surrounding medium. The potential advantage of imprinted polymerscapable of DDS is the longer presence of the drug withinbody. This can be done by reducing the rate at which the drug is released. In cases where the drug has a narrow therapeuticindex, MIP delivery vehicles might keep the concentration of the drug in the body below the concentration where adverse side effects become dominant.