Monitoring the Effect of Flow rate on Size and Morphology of Microspheres Produced by the Means of Electrospraying Method

There are numerous drug-delivery systems and the goal of most of these is to deliver medications intact to specific targets in the body through a medium that can control theadministration of therapy by means of either a physiological or chemical trigger. One of the most important characteristics to achieve this goal is particle size, which has a significant effect upon the in vivo behaviour such as circulation time, extravasation, targeting, immunogenicity, internalization,intracellular trafficking, degradation, flow properties, clearance and uptake mechanisms [1]. Electrohydrodynamic atomization (EHDA) is frequently usedin analytical chemistry for the production of highly charged, gas phase ions because size controllable near-monodisperse droplets are produced in electrohydrodynamic atomization, it has the potential for use in the production of controlled size polymer particles [2].