hMSC Osteogenic Differentiation on Biodegradable Poly (urethane urea)

Bone tissue engineering is an important approach through combination of living cells, biomatrices and biologically active molecules to provide new functionaltissue. [1] Bone marrow-derived mesenchymal stem cells (BMSC) are a powerful tool for tissue engineering because of self-renew and high differentiation potential. [2] Recently, we reported the preparation of thermoplastic segmented poly (urethane urea)s (PUU) based on polycaprolactone (PCL)through an one-pot system for bone tissue engineering applications. [3] In the present investigation, the bone marrowderived mesenchymal stem cells differentiation on the synthesized PUUs based on PCL/polyethylene glycol with different ratios into osteoblasts was studied.