Preparation of Crosslinked Hollow Dextran Microspheres Using Phase Separation Phenomena

Recently, porous and hollow polymer particles are widely studied due to their wide applications, such as encapsulating carriers for drug delivery, enzyme immobilization, cosmetics, fillers, toners,inks, catalysts, chromatographic packings and sound damping or absorption materials [1]. Significant progress has been made inthe design and synthesis of hollow polymer particles by a variety of physical and chemical methods [2].Here, crosslinked hollow microspheres are synthesized by addingnon-solvent to internal phase of an inverse emulsion system (W/O) and induction of phase separation during crosslinking of dextran chains. Effects of dextran and non-solvent concentrations on the resulting microspheres properties are investigated