Preparation of Alginate Nanoparticles for Target delivery of anti cancer Drugs

Biodegradable nanoparticles, with a particle size of about 100nm, have certain unique advantage in drug delivery [1]. Nanoparticles can penetrate small capillaries, allowingenhanced accumulation of nanoparticles-encapsulated drug at target sites. Nanoparticles can passively target tumor tissuethrough enhanced permeation and retention effect. Nanoparticles fabricated using synthetic polymers such as polylactides [2-3] or polyanhydrides are suitable deliveryvehicles for water-insoluble drugs. Thus, there is a clear need for nanoparticles formulations that can efficiently encapsulate and sustain the release of watersoluble,small molecular weight drug. We have developed a novel nanoparticle formation for water-soluble drugs, using Amphiphilic derivatives of sodium Alginate